The physiological functions of NOX family enzymes, include:

  • host defense
  • post-translational processing of proteins
  • cellular signalling
  • regulation of gene expression
  • cell differentiation

NOX enzymes also contribute to a wide range of pathological processes.

NOX deficiency may lead to:

  • immunosuppression
  • lack of otoconogenesis (the generation of calcium carbonate crystals, which play a role in controlling the hair cells of the ear, therefore hearing)
  • hypothyroidism
  • Increased NOX activity also contributes to a large number or pathologies, in particular metabolic and cardiovascular diseases and neurodegeneration.