Publishing is key to communicating the scientific progress we are making as we translate the science of NOX into viable drug candidates and ultimately towards the development of innovative medicines for patients.

 The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.

Somanna NK, Valente AJ, Krenz M, Fay WP, Delafontaine P, Chandrasekar B

J Cell Physiol. 2016 May;231(5):1130-41. doi: 10.1002/jcp.25210. Epub 2015 Oct 19.

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Early oxidative damage induced by doxorubicin: Source of production, protection by GKT137831 and effect on Ca2+ transporters in HL-1 cardiomyocytes.

Asensio-López MC, Soler F, Sánchez-Más J, Pascual-Figal D, Fernández-Belda F, Lax A

Arch Biochem Biophys. 2016 Feb 22;594:26-36. doi: 10.1016/j.abb.2016.02.021. [Epub ahead of print]

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NADPH oxidase 4 over-expression is associated with epithelial ciliary dysfunction in neutrophilic asthma.

Wan WH, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling C

Chest. 2016 Feb 2. pii: S0012-3692(16)00518-3. doi: 10.1016/j.chest.2016.01.024. [Epub ahead of print]

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NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

Hirschhäuser C, Bornbaum J, Reis A, Böhme S, Kaludercic N, Menabò R, Di Lisa F, Boengler K, Shah AM, Schulz R, Schmidt HH

Antioxid Redox Signal. 2015 Nov 10;23(14):1106-12. doi: 10.1089/ars.2014.6238. Epub 2015 Aug 3.

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Excess TGF-β mediates muscle weakness associated with bone metastases in mice.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA

Nat Med. 2015 Nov;21(11):1262-71. doi: 10.1038/nm.3961. Epub 2015 Oct 12.

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IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes

Rousset F, Hazane-Puch F, Pinosa C, Nguyen MV, Grange L, Soldini A, Rubens-Duval B, Dupuy C, Morel F, Lardy B

Osteoarthritis Cartilage. 2015 NOV;23(11):1972-80. doi: 10.1016/j.joca.2015.02.167.

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Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

You YH, Quach T, Saito R, Pham J, Sharma K.

J Am Soc Nephrol. 2015 Jul 22. pii: ASN.2015030302. [Epub ahead of print]

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NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

Vendrov AE, Vendrov KC, Smith A, Yuan J, Sumida A, Robidoux J, Runge MS, Madamanchi NR.

Antioxid Redox Signal. 2015 Jul 14. [Epub ahead of print]

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Increased Expression of NAPDH Oxidase 4 (NOX4) in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor ß

Piera-Velazquez S, Makul A, Jimenez SA.

Arthritis Rheumatol. 2015 Jun 19. doi: 10.1002/art.39242. [Epub ahead of print]

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Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ.

Gastroenterology. 2015 Aug;149(2):468-480.e10. doi: 10.1053/j.gastro.2015.04.009. Epub 2015 Apr 14.

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Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

Deliyanti D, Wilkinson-Berka JL.

J Neuroinflammation. 2015 Jul 30;12:136. doi: 10.1186/s12974-015-0363-z.

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

Lan T, Kisseleva T, Brenner DA.

PLoS One. 2015 Jul 29;10(7):e0129743. doi: 10.1371/journal.pone.0129743. eCollection 2015.

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Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox

Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM.

Hypertension. 2015 Sep;66(3):657-66. doi: 10.1161/HYPERTENSIONAHA.115.05616. Epub 2015 Jul 6.

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NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways

Zhao QD, Viswanadhapalli S, Williams P, Shi Q, Tan C, Yi X, Bhandari B, Abboud HE.

Circulation. 2015 Feb 17;131(7):643-55. doi: 10.1161/CIRCULATIONAHA.114.011079. Epub 2015 Jan 14.

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Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

Gorin Y, Cavaglieri RC, Khazim K, Lee DY, Bruno F, Thakur S, Fanti P, Szyndralewiez C, Barnes JL, Block K, Abboud HE.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014. Epub 2015 Feb 4.

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Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress

Choi DH, Kim JH, Seo JH, Lee J, Choi WS, Kim YS.

PLoS One. 2014 Dec 23;9(12):e115954. doi: 10.1371/journal.pone.0115954. eCollection 2014.

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Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

Zanetti F, Giacomello M, Donati Y, Carnesecchi S, Frieden M, Barazzone-Argiroffo C.

Free Radic Biol Med. 2014 Nov;76:173-84. doi: 10.1016/j.freeradbiomed.2014.08.002. Epub 2014 Aug 20.

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Premature skin aging features rescued by inhibition of NADPH oxidase activity in XPC-deficient mice

Hosseini M, Mahfouf W, Serrano-Sanchez M, Raad H, Harfouche G, Bonneu M, Claverol S, Mazurier F, Rossignol R, Taieb A, Rezvani HR.

J Invest Dermatol. 2015 Apr;135(4):1108-18. doi: 10.1038/jid.2014.511. Epub 2014 Dec 1.

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NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of acute respiratory distress syndrome.

Carnesecchi S, Dunand-Sauthier, Zanetti F, Singovski G, Deffert C, Donati Y, Cagarelli T, Pache JC, Krause KH, Reith W, Barazzone-Argiroffo C

Int J Clin Exp Pathol. 2014 Jan 15;7(2):537-51. eCollection 2014.

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy.

Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

J Am Soc Nephrol. 2014 Jun;25(6):1237-54. doi: 10.1681/ASN.2013070810.

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Reversal of persistent fibrosis in aging by targeting nox4-nrf2 redox imbalance.

Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ

Sci Transl Med. 2014 Apr 9;6(231):231ra47. doi: 10.1126/scitranslmed.3008182.

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Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe(-/-) mice

Di Marco E, Gray SP, Chew P, Koulis C, Ziegler A, Szyndralewiez C, Touyz RM, Schmidt HH, Cooper ME, Slattery R, Jandeleit-Dahm KA

Diabetologia. 2014 Mar;57(3):633-42. doi: 10.1007/s00125-013-3118-3. Epub 2013 Nov 30.

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Knock, knock: Who's there? Nox1. Circulation (2013)

Hana A. Itani, Sergey Dikalov and David G. Harrison

Circulation. 2013 May 7

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA

J Am Soc Nephrol. 2014 Feb 7.

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NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

Wilkinson-Berka JL, Deliyanti D, Rana I, Miller AG, Agrotis A, Armani R, Szyndralewiez C, Wingler K, Touyz RM, Cooper ME, Jandeleit-Dahm KA, Schmidt HH

Antioxid Redox Signal. 2013 Oct 30. [Epub ahead of print]

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Nox1 Plays a Key Role in Diabetes Accelerated Atherosclerosis. Circulation (2013).

Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA

Circulation. 2013 May 7

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Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013).

Gorin Y, Block K

Free Radic Biol Med. 2013 Mar 23

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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. Clinical Science (2013).

Sedeek M, Gutsol A, Montezano AC, Burger D, Nguyen Dinh CatA, Kennedy CR, Burns KD, Cooper ME, Jandeleit-Dahm K, Page P, Szyndralewiez C, Heitz F, Hebert RL, Touyz RM

Clinical Science, 2013 Feb 1; 124(3):191-202. doi: 10.1042/CS20120330

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The Nox4 Inhibitor, GKT137831, Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation. Am J Respir Cell Mol Biol (2012).

Green DE, Murphy TC, Kang BY, Kleinheinz JM, Szyndralewiez C, Page P, Sutliff RL, Hart CM

Am J Respir Cell Mol Biol. 2012 Sep 28. [Epub ahead of print] PMID:22904198

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Nicotinamide adenine dinucleotide phosphate oxidase (nox) in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012).

Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P, A Brenner D.

Hepatology. 2012 Jul 14. doi: 10.1002/hep.25938

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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012).

Joy X. Jiang, Xiangling Chen, Nobuko Serizawa, Cédric Szyndralewiez, Patrick Page, Katrin Schröder, Ralf P. Brandes, Sridevi Devaraj, Natalie J. Török

Free Radic Biol Med. 2012 Jul 15;53(2):289-96.

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NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem (2012).

Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A.

J Biol Chem. 2012 Mar 16;287(12):9376-88. Epub 2012 Jan 30.

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Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. J Am Soc Hypertens (2011).

Briones AM, Tabet F, Callera GE, Montezano AC, Yogi A, He Y, Quinn MT, Salaices M, Touyz RM.

J Am Soc Hypertens. 2011 May-Jun;5(3):137-53. Epub 2011 Mar 17.

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Design, Synthesis and Biological Activity of original Pyrazolo-Pyrido-Diazepine, -Pyrazine and -Oxazine Dione Derivatives as Novel Dual Nox4/Nox1 Inhibitors. Bioorganic and Medicinal Chemistry (2011).

F. Gaggini, B. Laleu, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, P. Page

Bioorganic and Medicinal Chemistry, 2011, Vol. 19, Issue 23, pp6989-6999.

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Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPAR-alpha Mediated Mechanism. PloS ONE (2011).

S. Garrido-Urbani, S. Jemelin, C. Deffert, S. Carnesecchi, O. Basset, C. Szyndralewiez, F. Heitz, P. Page, X. Montet, L. Michalik, J.L. Arbiser, C. Ruegg, B.A. Imhof

PloS ONE, 2011, Vol.6, Issue 11, e14665

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First-in-Class, Potent and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry (2010).

B. Laleu, F. Gaggini, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, P. Page

Journal of Medicinal Chemistry, 2010, 53 (21), 7715-30

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Critical Role of Nox4-Based NADPH oxidase in glucose-induced oxidative stress in kidney - Implications in type 2 diabetic nephropathy. American Journal of Physiology - Renal Physiology (2010).

M. Sedeek, G. Callera, A. Montezano, A. Gutsol, F. Heitz, C. Szyndralewiez, P. Page, C. Kennedy, K. Burns, R. Touyz, and R. Hebert

American Journal of Physiology - Renal Physiology, 2010, 299 (6), F1348-58

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NADPH oxidases regulates CD44 and hyaluronic acid expression in thrombin treated vascular smooth muscle cells and in atherosclerosis. Journal of Biological Chemistry (2010).

Vendrov A.E., Madamanchi N., Liu X.L., Molnar K.C., Runge M., Szyndralewiez C., Page P., Runge M.S.,

Journal of Biological Chemistry, 2010, 285, 26545-26557

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Computational toxicology: a tool for early safety evaluation. Drug Discovery Today (2010).

Cedric Merlot

Drug Discovery Today, 2010, Vol. 15, Numbers 1/2, pp16-22

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In silico methods for early toxicity assessment. Current Opinion in Drug Discovery & Development (2008).

Cedric Merlot

Current Opinion in Drug Discovery & Development, 2008, 11(1), pp80-85

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